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Noribogaine also elevates serotonin concentrations during the brain, a feasible explanation for its antidepressive results. The sustained presence of noribogaine in the CNS coupled with its agonist activity at opioid receptors may possibly make the self-tapering result in opiate-dependent individuals subsequent abrupt discontinuation of opiates. Additionally, ibogaine is able to change the expression of various proteins, material P, and brain-derived neurotrophic element. Noribogaine may be much less neurotoxic than ibogaine.Litjens 2016

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